Genetic defect in Klinefelter’s syndrome?
Correct Answer: XXY
Description: Ans. b (XXY) (Ref. H-17th/2340)KLINEFELTER'S SYNDROME# Most common chromosomal disorder associated with testicular dysfunction and male infertilty.# 1 in 1000 live-bom males.# Azoospermia is the rule in men with Klinefelter syndrome who have the 47, XXY karyotype.# Testicular histology :hyalinization of seminiferous tubules and absence of spermatogenesis. But number of Leydig cells appears to increase.# Testosterone is decreased and estradiol is increased.# Features:- Undervirilization and gynecomastia- Markedly reduced testicular volumes (1-2 mL)- Osteoporosis.# Increased risk of:- Breast cancer- NHL- Lung cancer.# Reduced risk of:- Prostate cancer.
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now