Gene for Wilm’s tumor is located on-
**Core Concept**
The Wilms tumor is a type of kidney cancer that primarily affects children. Genetic mutations play a crucial role in its development, and identifying the responsible gene is essential for understanding the underlying pathophysiology.
**Why the Correct Answer is Right**
The Wilms tumor gene (WT1) is a tumor suppressor gene located on the short arm of chromosome 11 (11p13). Mutations or deletions in this gene can lead to the development of Wilms tumor. The WT1 gene encodes a transcription factor that regulates the expression of other genes involved in kidney development and function. Proper function of the WT1 gene is critical for normal kidney maturation and maintenance.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because the WT1 gene is not associated with chromosome 1.
**Option B:** This option is incorrect because the WT1 gene is not linked to the long arm of chromosome 11.
**Option C:** This option is incorrect because the WT1 gene is not located on chromosome 16.
**Clinical Pearl / High-Yield Fact**
The WT1 gene is also associated with Denys-Drash syndrome, a rare genetic disorder characterized by Wilms tumor, nephropathy, and genital abnormalities.
**Correct Answer:** D. 11p13