**Core Concept**
Gaucher's disease is a lysosomal storage disorder caused by a deficiency of an enzyme involved in the breakdown of lipids, specifically glucocerebroside. This deficiency leads to the accumulation of glucocerebroside in various cells and organs, resulting in cellular dysfunction and tissue damage.

**Why the Correct Answer is Right**
The correct answer is glucocerebrosidase, an enzyme responsible for breaking down glucocerebroside into glucose and ceramide. A deficiency of glucocerebrosidase leads to the accumulation of glucocerebroside in lysosomes, causing cellular dysfunction and tissue damage. This deficiency is due to mutations in the GBA gene, which encodes the glucocerebrosidase enzyme.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as it does not relate to the metabolism of glucocerebroside.
**Option B:** This option is incorrect as it does not describe the enzyme responsible for breaking down glucocerebroside.
**Option C:** This option is incorrect as it is a different enzyme involved in lipid metabolism, not glucocerebrosidase.

**Clinical Pearl / High-Yield Fact**
Gaucher's disease is an autosomal recessive disorder, meaning that both parents must be carriers of the mutated GBA gene to pass it on to their offspring. This is an important consideration for genetic counseling and family planning.

**Correct Answer:** C. Glucocerebrosidase.