Gastrointestinal enteritis necroticans is caused by-
**Core Concept**
Gastrointestinal enteritis necroticans, also known as pigbel disease, is a severe form of enteritis characterized by necrosis of the intestinal mucosa. It is caused by a bacterium that produces a toxin responsible for the disease's pathogenesis.
**Why the Correct Answer is Right**
The correct answer is Clostridium perfringens type C. This bacterium produces a toxin that causes the necrosis of the intestinal mucosa, leading to the clinical manifestations of the disease. The toxin works by inhibiting the production of ATP in the intestinal mucosa, leading to cell death and tissue damage. The disease is particularly severe in children and young adults, and it can be fatal if left untreated.
**Why Each Wrong Option is Incorrect**
**Option A:** Clostridium difficile is a bacterium that causes pseudomembranous colitis, a different condition from enteritis necroticans. While it can cause severe diarrhea and colitis, it does not produce the toxin responsible for enteritis necroticans.
**Option B:** Bacillus cereus can cause food poisoning, but it is not associated with enteritis necroticans. The bacterium produces toxins that cause vomiting and diarrhea, but it does not cause the necrosis of the intestinal mucosa.
**Option C:** Escherichia coli can cause various forms of enteritis, including traveler's diarrhea and urinary tract infections, but it is not associated with enteritis necroticans.
**Clinical Pearl / High-Yield Fact**
Enteritis necroticans is a rare but severe condition that can be prevented by avoiding undercooked meat, particularly pork, and by ensuring proper food handling and storage.
**Correct Answer: C. Clostridium perfringens type C**