**Core Concept**
Gastrointestinal carcinoid tumors are a type of neuroendocrine tumor that arise from the enterochromaffin cells of the gastrointestinal tract. They can occur in various locations, including the small intestine, appendix, rectum, and other sites.

**Why the Correct Answer is Right**
The statement "**Rectum is spared**" is incorrect because carcinoid tumors can indeed occur in the rectum, although they are less common in this location compared to other parts of the gastrointestinal tract. In fact, rectal carcinoids are often found in the distal rectum, particularly in the region of the pectinate line.

**Why Each Wrong Option is Incorrect**
**Option A:** Small intestine and appendix account for almost 60% of all gastrointestinal carcinoid tumors, which is true. These two locations are the most common sites for carcinoid tumors to arise in the gastrointestinal tract.
**Option C:** The 5-year survival for carcinoid tumors is indeed > 60%, which is true. Carcinoid tumors have a relatively good prognosis, especially if they are diagnosed at an early stage and treated appropriately.
**Option D:** Appendiceal carcinoids are more common in females than males, which is true. Studies have shown that there is a female predominance in the incidence of appendiceal carcinoids.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that carcinoid tumors can be divided into three categories based on their size and location: small, submucosal carcinoids ( 2 cm). The size and location of the tumor significantly influence treatment decisions.

**✓ Correct Answer: B. Rectum is spared**