Gastric carcinoma is associated with all EXCEPT ?
Correct Answer: Activation of RAS
Description: Ans. is 'd' Activation of RAS In the course of multi-step stomach carcinogenesis, various genetic and epigenetic alterations of oncogenes, tumor-suppressor genes, DNA repair genes, cell cycle regulators and cell adhesion molecules are involved. Genetic alteration in gastric cancer include: Intestinal type gastric cancer: K-ras mutation, APC mutation, pS2 methylation, HMLH1 methylation, p I ema methylation, p 73 deletion and C-erb B-2 amplification. Diffuse type gastric caner: CDH I gene (E-Cadherin) mutation, K-sam amplification. For both type: Telomerase reduction (telomerase shoening), hTE expression, genetic instability, overexpression of the cyclin E & CDC25B & E2F I genes,p53 mutations, reduced expression, CD44 aberrabont transcripts, and amplification of the C-met Cyclin E genes. Coming to question: All the given four genetic alterations may be associated with stomach cancer. However among the given options K-ras is best answer as it is associated with gastric cancer in minimum percentage (amongst given options): Source: Textbook of mechanism of carcinogenesis and cancer prevention K-ras mutation -4 <10% p53 mutation 30-60% C-erb B-2 amplifcation --> 20% C-met amplifciation --> 20%
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now