Which of the following is NOT known as adverse drug reaction of furosemide?
**Core Concept**
Furosemide is a loop diuretic used to treat edema and hypertension by inhibiting the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle. Adverse drug reactions can occur due to its mechanism of action and effects on electrolyte balance and fluid status.
**Why the Correct Answer is Right**
Furosemide is known to cause various adverse reactions, including ototoxicity, which is due to its effect on the stria vascularis in the inner ear. This can lead to hearing loss, tinnitus, and vertigo. Another common adverse reaction is hypokalemia, which occurs due to increased potassium excretion in the urine. Additionally, furosemide can cause dehydration, hypovolemia, and metabolic alkalosis. However, one adverse reaction that is NOT commonly associated with furosemide is:
**Why Each Wrong Option is Incorrect**
**Option A:** Ototoxicity is indeed a known adverse reaction of furosemide.
**Option B:** Hypokalemia is also a well-known adverse effect of furosemide.
**Option C:** Dehydration and hypovolemia are common adverse reactions of furosemide.
**Clinical Pearl / High-Yield Fact**
It's essential to monitor patients on furosemide for signs of hypokalemia, as it can lead to cardiac arrhythmias and muscle weakness.
**Correct Answer: D.**