**Core Concept**
Kupffer cells are resident macrophages in the liver, playing a crucial role in maintaining liver health by removing foreign substances, debris, and microorganisms. They are part of the reticuloendothelial system, which is involved in the defense against infections and the clearance of waste products from the bloodstream.

**Why the Correct Answer is Right**
Kupffer cells recognize and phagocytose foreign particles, such as bacteria, dead cells, and cellular debris, through pattern recognition receptors like Toll-like receptors (TLRs) and scavenger receptors. They also participate in the activation of the complement system and the production of cytokines, which help to coordinate the immune response. Additionally, Kupffer cells contribute to the maintenance of liver homeostasis by regulating the availability of iron and the clearance of senescent red blood cells.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because Kupffer cells are not primarily involved in the production of bile.

**Option B:** This option is incorrect because Kupffer cells do not play a significant role in the storage of glycogen.

**Option C:** This option is incorrect because Kupffer cells do not function as a primary site for the detoxification of drugs.

**Clinical Pearl / High-Yield Fact**
Kupffer cells are responsible for the clearance of approximately 10-15% of the total blood volume that passes through the liver every minute, making them an essential component of the liver's defense mechanism.

**Correct Answer: C. Phagocytosis of foreign particles**