Following statements are true for propofol except: March 2012
## Core Concept
Propofol is a widely used intravenous anesthetic agent known for its rapid onset and short duration of action. It is commonly used for the induction and maintenance of general anesthesia or sedation. Propofol's mechanism of action is primarily through potentiation of the inhibitory neurotransmission mediated by **GABA (gamma-aminobutyric acid)**, specifically through the **GABA_A receptor**.
## Why the Correct Answer is Right
To accurately determine why the correct answer is right, the specific statements associated with options A, B, C, and D need to be evaluated. However, given that the question and specific details about the options are not provided, we'll proceed with general properties of propofol:
- Propofol is known for its antiemetic properties and is often associated with a reduced incidence of postoperative nausea and vomiting.
- It causes a decrease in blood pressure due to vasodilation and possibly a depressive effect on the heart.
- Propofol can cause pain on injection, which is a well-known side effect.
- The correct answer would relate to a statement that does not accurately describe propofol.
## Why Each Wrong Option is Incorrect
Without specific statements for A, B, C, and D, let's hypothetically analyze:
- **Option A:** If it states propofol is used for induction and maintenance of anesthesia, it's correct.
- **Option B:** If it mentions propofol causes pain on injection, it's correct.
- **Option C:** If it notes propofol has antiemetic effects, it's correct.
- **Option D:** If it claims propofol has a long duration of action, it's incorrect because propofol is known for its short duration of action.
## Clinical Pearl / High-Yield Fact
A key point to remember about propofol is that it can cause **pain on injection**, which can be mitigated by using larger veins, pre-administration of lidocaine, or cooling the solution. Additionally, propofol is often used in **sedation for procedures** due to its favorable pharmacokinetic profile, allowing for quick recovery.
## Correct Answer Line
Given the lack of specific details for each option, let's assume a common incorrect statement about propofol: **Correct Answer: D. [e.g., Propofol has a long duration of action].**