Following is true about Turners syndrome except-
**Turner Syndrome Overview**
Turner Syndrome is a genetic disorder in females characterized by the complete or partial absence of one X chromosome, resulting in monosomy X (45,X). This condition affects about 1 in 2,500 to 1 in 5,000 live-born females.
**Why the Correct Answer is Right**
Turner Syndrome is associated with a wide range of clinical features, including short stature, ovarian dysgenesis, and cardiovascular abnormalities. The short stature in Turner Syndrome is due to the absence of one X chromosome, which affects the growth hormone axis, leading to a deficiency in growth hormone secretion. Additionally, the ovarian dysgenesis in Turner Syndrome is caused by the failure of ovarian development due to the absence of the X chromosome, resulting in infertility.
**Why Each Wrong Option is Incorrect**
* **Option A:** Turner Syndrome is not associated with an increased risk of breast cancer. While there is an increased risk of autoimmune disorders, such as thyroiditis and diabetes, there is no significant association with breast cancer.
* **Option B:** Turner Syndrome is not characterized by an increased risk of ovarian cancer. In fact, the risk of ovarian cancer is significantly decreased in Turner Syndrome due to the absence of ovarian tissue.
* **Option C:** Turner Syndrome is not associated with an increased risk of schizophrenia. While there may be an increased risk of psychiatric disorders, such as anxiety and depression, there is no significant association with schizophrenia.
* **Option D:** Turner Syndrome is not characterized by an increased risk of osteoporosis. In fact, the risk of osteoporosis is significantly decreased in Turner Syndrome due to the absence of ovarian estrogen production, which would otherwise contribute to bone resorption.
**Clinical Pearl / High-Yield Fact**
Turner Syndrome is associated with a characteristic "shield chest" deformity due to the short stature and webbing of the neck. Additionally, the risk of cardiovascular abnormalities, such as bicuspid aortic valve and coarctation of the aorta, is significantly increased in Turner Syndrome.
**Correct Answer: D. Turner Syndrome is not characterized by an increased risk of osteoporosis.**