Following is true about C reactive protein –
**Core Concept**
C-reactive protein (CRP) is an acute-phase protein that increases in response to inflammation, infection, and tissue damage. It is produced in the liver and serves as a marker for systemic inflammation, with elevated levels indicating an inflammatory process.
**Why the Correct Answer is Right**
CRP binds to the surface of apoptotic cells, bacteria, and other foreign substances, marking them for removal by the immune system. This process involves the complement system and phagocytic cells, which work together to clear the body of pathogens and damaged cells. CRP also inhibits the activity of certain proteases, further contributing to its anti-inflammatory effects.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because CRP is not a direct anti-inflammatory mediator, but rather a marker of inflammation. While it has some anti-inflammatory properties, its primary role is to indicate the presence of an inflammatory process.
**Option B:** This option is incorrect because CRP is not produced by neutrophils. It is produced in the liver in response to inflammatory cytokines, such as IL-6.
**Option C:** This option is incorrect because CRP is not a direct inhibitor of the complement system. While it does bind to the surface of foreign substances and mark them for removal, it does not directly inhibit the complement cascade.
**Clinical Pearl / High-Yield Fact**
Elevated CRP levels can be seen in a variety of conditions, including infections (bacterial, viral, fungal), autoimmune diseases (rheumatoid arthritis, lupus), and malignancies. A high CRP level in the absence of an obvious cause should prompt further investigation to identify the underlying condition.
**Correct Answer:** A.