**Core Concept**
Randomization is a fundamental principle in clinical trials and research studies, used to minimize bias and ensure the validity of results. It involves the process of assigning participants to different groups, such as treatment or control, in a way that is unpredictable and not based on any identifiable characteristics.

**Why the Correct Answer is Right**
Randomization helps to eliminate selection bias by ensuring that each participant has an equal chance of being assigned to any group. This is particularly important in studies where there may be differences between participants that could affect the outcome, such as age, gender, or socioeconomic status. By randomizing participants, researchers can minimize the impact of these differences and ensure that the results are more generalizable to the population as a whole.

**Why Each Wrong Option is Incorrect**
**Option A:**
Randomization allows for the comparison of treatment groups, which is essential for determining the effectiveness of a new intervention. This is the primary benefit of randomization.

**Option B:**
Randomization helps to reduce the risk of confounding variables, which can affect the outcome of a study. By randomly assigning participants to groups, researchers can minimize the impact of these variables.

**Option C:**
Randomization allows for the estimation of treatment effects, which is critical for determining the efficacy of a new intervention. This is a key benefit of randomization.

**Clinical Pearl / High-Yield Fact**
A key advantage of randomization is that it allows researchers to estimate the treatment effect with greater precision, which is essential for making informed decisions about the use of new interventions.

**Correct Answer:** None of the above options are correct.