Following are seen in fibrous dysplasia EXCEPT September 2004
**Core Concept**
Fibrous dysplasia is a benign bone disorder characterized by the replacement of normal bone tissue with fibrous connective tissue, leading to weakened bones and potential deformities. This condition often affects the skull, long bones, and pelvis.
**Why the Correct Answer is Right**
Fibrous dysplasia involves the replacement of normal bone cells with fibroblasts and osteoblasts, leading to the formation of abnormal bone tissue. The condition is often associated with an overgrowth of fibrous tissue, which can cause bones to become weakened and susceptible to fractures. The affected bones may also become deformed, leading to characteristic facial features and skeletal abnormalities. The pathophysiology of fibrous dysplasia is complex and involves the interplay of various cellular and molecular mechanisms.
**Why Each Wrong Option is Incorrect**
**Option A:** McKeown's triad is associated with fibrous dysplasia, which includes a combination of fibrous dysplasia, polyostotic fibrous dysplasia, and café-au-lait spots. Therefore, this option is incorrect as it is indeed seen in fibrous dysplasia.
**Option B:** Albright's syndrome is a condition that includes polyostotic fibrous dysplasia, café-au-lait spots, and precocious puberty, which is associated with fibrous dysplasia. Therefore, this option is incorrect as it is indeed seen in fibrous dysplasia.
**Option C:** This option is not provided in the question.
**Option D:** This option is not provided in the question.
**Clinical Pearl / High-Yield Fact**
A classic clinical feature of fibrous dysplasia is the presence of café-au-lait spots, which are areas of skin discoloration that can be seen in affected individuals. These spots are a result of the abnormal growth of melanocytes and are often associated with other systemic manifestations of the condition.
**Correct Answer:** None of the above options (A, B, C, D) are provided in the question. To provide a correct explanation, the actual options would need to be provided.