True statement regarding follicular cell carcinoma of thyroid: (D. REPEAT 2013)
**Core Concept**
Follicular cell carcinoma (FCC) of the thyroid is a type of malignant tumor originating from the follicular cells of the thyroid gland. It is one of the two main types of differentiated thyroid cancer, along with papillary thyroid carcinoma. FCC is characterized by its ability to metastasize through the bloodstream, leading to distant metastases.
**Why the Correct Answer is Right**
The correct answer is related to the histopathological and clinical features of FCC. Follicular cell carcinoma is known for its tendency to metastasize to distant sites, including the bones, lungs, and liver. This is due to the ability of cancer cells to break away from the primary tumor and enter the bloodstream, a process known as hematogenous spread. The cancer cells then lodge in distant organs and form new tumors.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not accurately describe a characteristic of follicular cell carcinoma. While FCC can cause local destruction of surrounding tissues, it is not the most distinctive feature of this type of cancer.
**Option B:** This option is incorrect because it is not a true statement about follicular cell carcinoma. Papillary thyroid carcinoma, not FCC, is known for its association with radiation exposure.
**Option C:** This option is incorrect because it is not a specific characteristic of follicular cell carcinoma. While both papillary and follicular thyroid cancers can occur in young individuals, this is not a unique feature of FCC.
**Clinical Pearl / High-Yield Fact**
A key clinical feature of follicular cell carcinoma is its ability to metastasize to distant sites through the bloodstream. This is in contrast to papillary thyroid carcinoma, which tends to spread through lymphatic channels.
**Correct Answer: D. Follicular cell carcinoma is known for its ability to metastasize through the bloodstream, leading to distant metastases.**