Fluroquinolone mechanism of action in gram positive organism is by –

Correct Answer: Topoisomerase IV
Description: Ans. is 'd' i.e., Topoisomerase IV o The FQs inhibit the enzyme enzyme bacterial DNA gyrase in gram negative bacteria. In the gram - positive bacteria the major target of FQ action is a similar enzyme topoisomerase IV which nicks and separates daughter DNA strands after DNA replication.
Category: Pharmacology
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