**Core Concept**
Flumazenil is a benzodiazepine receptor antagonist that reverses the effects of benzodiazepines. Its duration of action is an essential consideration in clinical practice, particularly in the management of benzodiazepine overdoses.

**Why the Correct Answer is Right**
Flumazenil's duration of action is relatively short, typically lasting around 1-2 hours. This is because flumazenil is rapidly metabolized by cytochrome P450 enzymes, primarily CYP3A4, in the liver. The rapid metabolism of flumazenil leads to a short half-life, which in turn, affects its duration of action. The clinical significance of flumazenil's short duration of action is that it may require repeated dosing to maintain its effects, particularly in cases of prolonged benzodiazepine exposure.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not accurately reflect the established duration of action of flumazenil. While flumazenil's effects may last for several hours in some cases, its typical duration of action is shorter.

**Option B:** This option is incorrect because it overestimates the duration of action of flumazenil. While flumazenil may be used in cases of prolonged benzodiazepine exposure, its own duration of action is not as long as this option suggests.

**Option D:** This option is incorrect because it underestimates the duration of action of flumazenil. While flumazenil's effects may wane over time, its duration of action is generally longer than this option suggests.

**Clinical Pearl / High-Yield Fact**
In clinical practice, the duration of action of flumazenil should be carefully considered when managing benzodiazepine overdoses. Repeated dosing may be necessary to maintain the effects of flumazenil, particularly in cases of prolonged benzodiazepine exposure.

**Correct Answer: C. 1-2 hours**