Fifth clinical sign i.e., loss of function (functio laesa) was added by:

Correct Answer: Rudolf Virchow
Description: Acute inflammation Four cardinal signs of inflammation was given by Celsus. Rubor (redness) Tumor (swelling) Calor (heat) Dolor (pain). These signs are hallmarks of acute inflammation. A fifth clinical sign, loss of function (functio laesa), was added by Rudolf Virchow in the 19th century. Metchinkoff described process of phagocytosis.
Category: Pathology
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