All of the following are true about fibrolamellar carcinoma of the liver except –
**Core Concept**
Fibrolamellar carcinoma (FLC) is a rare subtype of hepatocellular carcinoma (HCC), characterized by its distinct histological features, including a lack of cirrhosis and a younger age of presentation. It is often associated with a better prognosis compared to conventional HCC.
**Why the Correct Answer is Right**
Fibrolamellar carcinoma typically presents in young adults without underlying liver disease, such as cirrhosis, which is a key distinguishing feature from conventional HCC. The tumor is also often well-circumscribed and can be resectable, leading to improved survival rates. The molecular pathogenesis of FLC is not fully understood, but it is thought to involve genetic alterations, including mutations in the CTNNB1 gene.
**Why Each Wrong Option is Incorrect**
**Option A:** This statement is true about fibrolamellar carcinoma, as it is often associated with a younger age of presentation, typically in the second to fourth decade of life.
**Option B:** This statement is also true about fibrolamellar carcinoma, as it is characterized by its distinct histological features, including a lack of cirrhosis and a trabecular or cord-like growth pattern.
**Option C:** This statement is true about fibrolamellar carcinoma, as it is often well-circumscribed and can be resectable, leading to improved survival rates.
**Clinical Pearl / High-Yield Fact**
It's essential to note that fibrolamellar carcinoma is a rare subtype of HCC, and its diagnosis often requires a combination of clinical, radiological, and histopathological features. A high index of suspicion and awareness of its distinct characteristics are crucial for early detection and treatment.
**Correct Answer: A.**