Fibroblast proliferation is stimulated by?
Correct Answer: TGF-β
Description: “TFG-β is practically always involved as an important fibrogenic agent” - Robbins
• The most important fibrogenic mediator (causing fibrosis) is transforming growth factor- β. It induces the proliferation of fibroblasts, endothelial cells and specialized fibrogenic cells. It is chemotactic for fibroblasts, neutrophils, macrophages, lymphocytes and smooth muscle cells.
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Pathology
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