Q fever is caused by –
**Core Concept**
Q fever is a zoonotic disease caused by a bacterium that can be transmitted to humans through inhalation of contaminated dust particles or direct contact with infected animals. The causative agent is an obligate intracellular pathogen that exhibits unique survival properties in the environment.
**Why the Correct Answer is Right**
Coxiella burnetii is the correct answer because it is the only obligate intracellular bacterium listed that is known to cause Q fever. This bacterium has a unique ability to survive outside of a host for extended periods, allowing it to be transmitted through various routes. Coxiella burnetii is typically found in ticks, cattle, and sheep, and can be transmitted to humans through inhalation of contaminated dust particles or direct contact with infected animals.
**Why Each Wrong Option is Incorrect**
**Option A:** Pseudomonas is a genus of Gram-negative bacteria that includes Pseudomonas aeruginosa, which causes opportunistic infections in humans. However, it is not associated with Q fever.
**Option B:** Francisella is a genus of Gram-negative bacteria that includes Francisella tularensis, which causes tularemia, a disease distinct from Q fever.
**Option D:** Rickettsia typhi is a bacterium that causes murine typhus, a different disease from Q fever.
**Clinical Pearl / High-Yield Fact**
Q fever can manifest in two forms: acute and chronic. Acute Q fever typically presents with symptoms such as fever, headache, and pneumonia, while chronic Q fever is characterized by endocarditis and is often seen in immunocompromised individuals.
**β Correct Answer: C. Coxiella burnetii**