**Question:** True of testicular feminization syndrome is:nnA) Testes are presentnB) Female HabitusnC) XY genotypenD) Uterus presentnnA.
B.
C.
D.

**Correct Answer:** .nn**Core Concept:**nnTesticular feminization syndrome (TFS) is a rare condition characterized by ambiguous genitalia in males with an XY karyotype. It is caused by defects in the androgen biosynthesis pathway, leading to reduced testosterone production and decreased virilization of external genitalia. The syndrome results in the development of secondary sexual characteristics more typical of females.nn**Why the Correct Answer is Right:**nnCorrect Answer D (Uterus present) is incorrect as TFS is characterized by a deficiency of functional testosterone, which leads to reduced virilization and ambiguous genitalia. The presence of a uterus is not a feature of TFS.nnCorrect Answer A (Testicles present) is also incorrect. Although the affected individuals have XY chromosomes, the reduced testosterone production results in the development of ambiguous genitalia and secondary sexual characteristics typical of females, not males. This is due to the absence of functional testosterone, which is crucial for male genital development.nnCorrect Answer B (Female Habitus) is a core feature of TFS as the deficiency of functional testosterone results in the development of secondary sexual characteristics typical of females, leading to a female-like physical appearance despite the XY chromosomes.nnCorrect Answer C (XY Genotype) is right as TFS is characterized by an XY karyotype, which is typical of males. However, the condition results from defects in the androgen biosynthesis pathway leading to reduced testosterone production.nnIn summary, Testicular feminization syndrome is a condition characterized by ambiguous genitalia in males with an XY karyotype due to defects in the androgen biosynthesis pathway. The condition results in the development of secondary sexual characteristics typical of females, despite the presence of functional testes. The correct answer is XY genotype (C), female habitus (B), and the absence of a uterus (D).