Febrile response in CNS is mediated by all except
Correct Answer: IL-6
Description: Fever is produced in response to substances called pyrogens that act by stimulating prostaglandin synthesis in the vascular and perivascular cells of hypothalamus.
They can be classified as:
Exogenous pyrogens - Endotoxin of gram ‘-’ bacteria, superantigens (gram ‘+’ bacteria).
Endogenous pyrogens - IL-1, TNF-alpha, Ciliary neurotropic factor and IFN-alpha.
PGE 2 is the most important chemical responsible for elevation of hypothalamic set point in the body.
So, NSAIDs reduce fever by inhibiting cyclooxygenase and reducing prostaglandin concentration.
Category:
Pathology
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