**Core Concept**
Tuberous sclerosis complex (TSC) is a genetic disorder characterized by the growth of non-cancerous tumors in various parts of the body, including the skin, brain, kidneys, and other organs. This condition is caused by mutations in the TSC1 or TSC2 genes, leading to the activation of the mechanistic target of rapamycin (mTOR) pathway, which regulates cell growth and proliferation.

**Why the Correct Answer is Right**
The correct answer will be a feature that is not typical of tuberous sclerosis. TSC is characterized by the development of hamartomas, which are benign tumors composed of normal tissue elements. The condition can affect multiple organ systems, including the skin (adenoma sebaceum, ash-leaf spots), brain (subependymal giant cell astrocytomas), kidneys (angiomyolipomas), and heart (rhabdomyomas).

**Why Each Wrong Option is Incorrect**
**Option A:**
This option is incorrect because it is a known feature of tuberous sclerosis. Adenoma sebaceum, also known as angiofibromas, is a characteristic skin manifestation of the condition.

**Option B:**
This option is incorrect because it is a known feature of tuberous sclerosis. Subependymal giant cell astrocytomas (SEGAs) are a type of brain tumor that can occur in individuals with TSC.

**Option C:**
This option is incorrect because it is a known feature of tuberous sclerosis. Angiomyolipomas are benign tumors of the kidney that can occur in individuals with TSC.

**Clinical Pearl / High-Yield Fact**
One important aspect of tuberous sclerosis is the risk of developing subependymal giant cell astrocytomas (SEGAs), which can cause hydrocephalus and other neurological symptoms. Early diagnosis and treatment of SEGAs are crucial to prevent complications.

**Correct Answer: D.**