**Question:** Features of opioid intake are all of the following except:

A. Drowsiness
B. Respiratory depression
C. Gastrointestinal motility suppression
D. Increased blood pressure and heart rate

**Core Concept:** Opioids are a class of drugs that act on the central nervous system to produce analgesia (pain relief), sedation, and respiratory depression. They bind to opioid receptors (μ, κ, and δ) in the brain, spinal cord, and gastrointestinal tract.

**Why the Correct Answer is Right:** The correct answer, **D. Increased blood pressure and heart rate**, is not a feature of opioid intake because opioids primarily act on the cardiovascular system by inhibiting the release of norepinephrine and reducing sympathetic activity. This leads to hypotension (decreased blood pressure) and bradycardia (slow heart rate), not increased blood pressure and heart rate.

**Why Each Wrong Option is Incorrect:**

A. Drowsiness: Opioids are known for producing sedation and drowsiness as a result of their action on the central nervous system.
B. Increased blood pressure and heart rate: As mentioned above, opioids actually lower blood pressure and heart rate due to their effect on sympathetic nervous system inhibition.
C. Gastrointestinal motility suppression: Opioids can indeed slow down gastrointestinal motility, which is a common side effect.

**Clinical Pearl:** In clinical practice, opiate overdose can lead to severe hypotension and bradycardia, which may require intervention such as naloxone administration to reverse the effects of the opioids. Understanding the pharmacological effects of opioids is essential for safe and effective use in pain management and emergency situations.