Reye’s syndrome is characterized by encephalitis, fatty liver and following biochemical changes except –
**Core Concept**
Reye's syndrome is a rare but serious condition that affects the brain and liver, particularly in children and adolescents recovering from a viral infection, such as influenza or chickenpox. It is characterized by the development of encephalitis, fatty liver, and specific biochemical changes.
**Why the Correct Answer is Right**
Reye's syndrome is associated with the accumulation of very-long-chain fatty acids (VLCFAs) in the liver, which leads to the depletion of ATP and the disruption of mitochondrial function. This results in the production of lactic acid, which is a key biochemical marker of the syndrome. Additionally, Reye's syndrome is also characterized by an increase in the levels of ammonia and a decrease in the levels of carnitine.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is not a characteristic biochemical change of Reye's syndrome. However, the specific biochemical changes associated with Reye's syndrome are not listed here, so we cannot determine which option is incorrect based on the information provided.
**Option B:** This option is incorrect because Reye's syndrome is actually associated with a decrease in the levels of carnitine.
**Option C:** This option is incorrect because Reye's syndrome is associated with an increase in the levels of ammonia, not a decrease.
**Clinical Pearl / High-Yield Fact**
Reye's syndrome is often associated with the use of aspirin in children and adolescents recovering from a viral infection. The use of aspirin in these patients should be avoided, as it may increase the risk of developing Reye's syndrome.
**Correct Answer:** None of the above (since the options were not provided)