False statement regarding DIC is: March 2011
**Core Concept**
Disseminated Intravascular Coagulation (DIC) is a complex condition characterized by both widespread clotting and bleeding in the vascular system. It involves the consumption of clotting factors and platelets, leading to a pro-coagulant state and subsequent thrombosis, along with a paradoxical bleeding tendency due to the depletion of these essential components.
**Why the Correct Answer is Right**
DIC is a condition where the normal balance between coagulation and fibrinolysis is disrupted, leading to an excessive activation of the coagulation cascade. This results in the formation of numerous microthrombi throughout the microvasculature, which consume platelets and clotting factors. The depletion of these essential components impairs the body's ability to form new clots, thereby increasing the risk of bleeding. The pathophysiology of DIC is closely linked to the release of tissue factor, which triggers the extrinsic coagulation pathway.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because DIC is indeed characterized by the formation of microthrombi, which consume platelets and clotting factors, leading to a consumptive coagulopathy.
**Option B:** This option is incorrect because thrombocytopenia is a hallmark of DIC, resulting from the consumption of platelets in the formation of microthrombi.
**Option C:** This option is incorrect because the bleeding tendency in DIC is not solely due to platelet dysfunction, but rather due to the depletion of clotting factors and platelets.
**Clinical Pearl / High-Yield Fact**
DIC can be triggered by a variety of conditions, including sepsis, trauma, and malignancy. The diagnosis of DIC is often based on clinical criteria, including the presence of thrombocytopenia, prolonged coagulation times, and the presence of fibrin degradation products.
**Correct Answer: B. Thrombocytopenia is not a cause of DIC.**