False regarding levels of cardiac biomarkers following ischemic injury to the heart
Correct Answer: Troponin returns to normal in three days
Description: Answer: b) Troponin returns to normal in three days (HARRISON 19TH ED, P-1600)SERUM CARDIAC BIOMARKERSCKCardiac Troponins* CK-MB - most sensitive early marker (but overall less sensitive than troponin), but not specific* Starts to rise within 4-12 hrs, peaks at 24 hrs, falls to normal in 48-72 hrs* CK(but not CK-MB) also rises in i.m injection, exercise, skeletal muscle disease and trauma* CK-MB often rises after cardiac surgery, myocarditis, electrical cardioversion* Test of choice to diagnose re infarct* cTnT and cTnl - contractile proteins normally not present in serum* Most sensitive and specific markers of myocardial damage* cTnl - highly sensitive for damage to cardiac tissue* Rise within 2-6 hrs* peaks at 12-18 hours; normalizes at 5-10 days* The risk of death from an acute coronary syndrome is directly related to troponin level and patients with no detectable troponins have a good short-term prognosis* Minor troponin elevations seen in: CHF, myocarditis, pul. embolism* Elevated levels of CPK-MB and Troponins distinguish patients with NSTEMI from those with UA* 99th percentile cutoff point for troponin T (cTnT) is - 0.01 ng/mLMyoglobin is released more rapidly (within 2 hrs) from infracted myocardium; useful for detection of early reinfarctionB-type Natriuretic peptide(BNP) levels also rise after acute coronary syndromesMRI with gadolinium contrast enhancement - most sensitive to detect and quantitate extent of infarctionUp to 80% of patients with acute Ml will have an elevated troponin level within 2-3 hours of emergency department (ED) arrival, versus 6-9 hours or more with CK-MB and other cardiac markers ( style="font-size: 1.04761904761905em; font-family: Times New Roman, Times, serif">)
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now