False about lymphoma in AIDS patients
Correct Answer: Less responsive to treatment
Description: Ans: d (less respon...). Ref: Harrison 17th ed/ p. 1188, 1189The treatment response for lymphoma in AIDS patient is as high as 72%Lymphoma in AIDSClinical features* High grade* Lymphadenopathy* Extranodal involvement- most common site is CNS* Disseminated diseaseThree main categories of lymphoma are seen in patients with HIV infection:-* Grade III or IV immunoblastic lymphoma* Burkitf s lymphoma* Primary CNS lymphomai) Immunoblastic lymphoma* 60% of the cases of lymphoma in patients with AIDS.* High grade* Seen in older patients* One variant - body cavity lymphoma (lymphomatous pleural, pericardial, peritoneal effusions in absence of intranodal or extranodal masses).* HHV-8 DNA sequences in these malignant cellsii) Burkitt's lymphoma (small noncleaved cell lymphoma)* 20% of cases* Seen in 10-19 years old* Characteristic c-myc translocations from chromosome 8 to chromosome 14 or 22* Only 50% of HIV associated Burkitt's lymphoma are EB V-positive.iii) Primary CNS lymphoma* 20% of cases* No age predilection* EBV positive* Seen in later stage of HIV, so poorer prognosis.Response to treatment is as high 72%.Note:-Multicentric Castleman's disease is a HHV-8 associated lymphoproliferative disorder.Lymph node biopsies show onion skin appearance (hyaline vascular)
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now