False about Krabbe’s disease
**Core Concept**
Krabbe's disease, also known as globoid cell leukodystrophy, is a rare, inherited disorder caused by a deficiency of the enzyme galactosylceramidase (GALC). This enzyme is responsible for breaking down certain fatty substances in the brain and spinal cord.
**Why the Correct Answer is Right**
Krabbe's disease is characterized by the accumulation of toxic substances in the brain and spinal cord, leading to progressive damage and degeneration of the myelin sheath. This results in impaired nerve conduction, causing a range of neurological symptoms. The disease is caused by mutations in the GALC gene, which codes for the enzyme responsible for breaking down galactosylceramide.
**Why Each Wrong Option is Incorrect**
**Option A:** Krabbe's disease is caused by a deficiency of the enzyme galactosylceramidase (GALC). While this is true, it's not the correct answer since the question asks for what is false about Krabbe's disease.
**Option B:** Krabbe's disease is a genetic disorder. This statement is true and not the correct answer.
**Option C:** Krabbe's disease is an autoimmune disorder. This statement is false, as Krabbe's disease is caused by a deficiency of the enzyme galactosylceramidase (GALC), not an autoimmune response.
**Option D:** Krabbe's disease is characterized by the accumulation of toxic substances in the brain and spinal cord. This statement is true and not the correct answer.
**Clinical Pearl / High-Yield Fact**
Krabbe's disease is one of several leukodystrophies, a group of rare genetic disorders that affect the myelin sheath in the central nervous system.
**Correct Answer: C. Krabbe's disease is an autoimmune disorder.