False about Japanese encephalitis is-
**Core Concept**
Japanese encephalitis (JE) is a zoonotic disease caused by a flavivirus that primarily affects the central nervous system. The virus is transmitted to humans through the bite of an infected mosquito, mainly the Culex tritaeniorhynchus species.
**Why the Correct Answer is Right**
The correct answer is related to the transmission cycle of JE virus. The virus is primarily maintained in a cycle between mosquitoes and pigs, with water birds serving as a dead-end host. Humans become incidental hosts when they are bitten by infected mosquitoes. The correct answer will highlight a misconception about the primary host or transmission vector of JE virus.
**Why Each Wrong Option is Incorrect**
**Option A:** JE virus is primarily transmitted through the bite of an infected mosquito. This option is incorrect as it does not specify the primary host or vector involved in the transmission cycle.
**Option B:** JE virus is mainly maintained in a cycle between mosquitoes and humans. This option is incorrect as it incorrectly identifies humans as the primary host, rather than pigs.
**Option C:** JE virus is primarily transmitted through the bite of an infected tick. This option is incorrect as it incorrectly identifies a tick as the primary vector, rather than a mosquito.
**Clinical Pearl / High-Yield Fact**
It's essential to note that the JE vaccine is a live attenuated vaccine that provides long-term immunity, and its administration is recommended for individuals traveling to endemic areas, especially during peak transmission seasons.
**Correct Answer: C. JE virus is primarily transmitted through the bite of an infected tick.**