False about folic acid
**Core Concept**
Folic acid, also known as vitamin B9, is a crucial water-soluble vitamin involved in various bodily functions, including DNA synthesis, cell division, and the metabolism of amino acids. It plays a vital role in preventing megaloblastic anemia and is essential for fetal development during pregnancy.
**Why the Correct Answer is Right**
Folic acid is absorbed in the small intestine through a carrier-mediated transport process. It is then converted into its active form, tetrahydrofolate (THF), by the enzyme dihydrofolate reductase (DHFR). THF is essential for the synthesis of purines and pyrimidines, which are the building blocks of DNA. Moreover, folic acid is required for the metabolism of homocysteine, an amino acid that, when elevated, can lead to cardiovascular disease.
**Why Each Wrong Option is Incorrect**
**Option A:** Folic acid is not necessary for the metabolism of carbohydrates. While it's true that folic acid is involved in the metabolism of amino acids, it's not directly related to carbohydrate metabolism.
**Option B:** Folic acid supplementation does not directly increase the risk of cancer. However, high doses of folic acid can mask the effects of vitamin B12 deficiency, which can lead to an increased risk of certain cancers.
**Option C:** Folic acid is not directly involved in the regulation of blood pressure. However, it's essential for the metabolism of homocysteine, which can contribute to endothelial dysfunction and hypertension.
**Option D:** Folic acid deficiency does not directly cause hyperthyroidism. However, it's essential for the metabolism of amino acids, which can affect thyroid function indirectly.
**Clinical Pearl / High-Yield Fact**
Folic acid deficiency can cause megaloblastic anemia, characterized by large, immature red blood cells. It's essential to note that folic acid supplementation can mask the effects of vitamin B12 deficiency, which can lead to neurological damage if left untreated.
**Correct Answer: D. Folic acid deficiency does not directly cause hyperthyroidism.**