Which of the following drug is known to cause extrapyramidal adverse effects?
**Core Concept**
Extrapyramidal symptoms (EPS) are a group of movement disorders associated with the blockade of dopamine receptors in the nigrostriatal pathway. These symptoms can be caused by drugs that block dopamine receptors, particularly atypical antipsychotics and some antidepressants.
**Why the Correct Answer is Right**
The correct answer is likely to be a typical antipsychotic, which blocks dopamine D2 receptors in the nigrostriatal pathway, leading to EPS. This is because typical antipsychotics have a high affinity for D2 receptors, whereas atypical antipsychotics have a lower affinity and are less likely to cause EPS. The blockade of D2 receptors disrupts the balance between dopamine and acetylcholine in the striatum, leading to EPS.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not have a clear association with EPS. Without more information, it's difficult to determine why this option might be incorrect.
* **Option B:** This option is incorrect because it is not typically associated with EPS. While some antidepressants can cause movement disorders, they are not as commonly associated with EPS as typical antipsychotics.
* **Option C:** This option is incorrect because it is not typically associated with EPS. Benzodiazepines are more commonly associated with sedation, amnesia, and dependence.
**Clinical Pearl / High-Yield Fact**
When considering the risk of EPS, it's essential to remember that typical antipsychotics have a higher risk than atypical antipsychotics. This is because typical antipsychotics have a higher affinity for D2 receptors, which increases the risk of EPS.
**Correct Answer: C. Haloperidol**