Extracellular adenosine is increased by which of the following DMARDs?
Correct Answer: Methotrexate
Description: Methotrexate: Methotrexate inhibits an enzyme 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase leading to accumulation of AICAR, which blocks adenosine deaminase. Thus adenosine accumulates and it decreases inflammation by acting on adenosine receptors.
Category:
Pharmacology
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