**Core Concept**
The question is testing the understanding of urticaria, specifically the histopathological features of an allergic reaction. Urticaria is characterized by the release of histamine and other mediators from mast cells, leading to increased vascular permeability and smooth muscle contraction.

**Why the Correct Answer is Right**
In an allergic reaction, the body's immune system mistakenly identifies a harmless substance (in this case, seafood) as a threat. This triggers the release of histamine and other chemical mediators from mast cells, leading to the characteristic symptoms of urticaria, including pruritic wheals. A biopsy of a urticarial lesion would likely demonstrate the presence of mast cells degranulating and releasing histamine, leading to the characteristic histopathological features.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is not a specific histopathological feature of an allergic reaction. While inflammation is a general feature of many skin conditions, it is not a specific characteristic of urticaria.
**Option B:** This option is incorrect because it is a feature of contact dermatitis, a different type of skin reaction that is caused by direct contact with an allergen, rather than an allergic reaction to a ingested substance.

**Clinical Pearl / High-Yield Fact**
Urticaria can be caused by a variety of factors, including allergies, infections, and autoimmunity. It is often associated with the release of histamine and other chemical mediators from mast cells, leading to increased vascular permeability and smooth muscle contraction.

**Correct Answer:** C.