## Core Concept
The question tests the understanding of antimicrobial resistance, specifically extended-spectrum beta-lactamases (ESBLs), and the selection of appropriate antibiotics to combat infections caused by ESBL-producing organisms. ESBLs are enzymes produced by certain bacteria that confer resistance to most beta-lactam antibiotics, including penicillins, cephalosporins, and aztreonam.
## Why the Correct Answer is Right
The correct answer, , is effective against organisms producing ESBL because it is a carbapenem antibiotic. Carbapenems are a class of beta-lactam antibiotics that are generally stable against beta-lactamase degradation, including ESBLs. They have a broad spectrum of activity and are often considered drugs of choice for treating serious infections caused by ESBL-producing bacteria.
## Why Each Wrong Option is Incorrect
* **Option A:** is incorrect because it is a cephalosporin antibiotic, which is likely to be ineffective against ESBL-producing organisms due to its susceptibility to degradation by ESBL enzymes.
* **Option B:** is incorrect because, although it might have some activity against certain Gram-positive bacteria, it is not reliably effective against ESBL-producing organisms.
* **Option D:** is incorrect because, similar to option A, it is also a cephalosporin and would not be effective against bacteria producing ESBL.
## Clinical Pearl / High-Yield Fact
A key point to remember is that carbapenems (like ) are often the drugs of choice for treating infections caused by ESBL-producing bacteria. However, the emergence of carbapenem-resistant Enterobacteriaceae (CRE) poses a significant challenge. Always consider local resistance patterns when choosing an antibiotic.
## Correct Answer Line
**Correct Answer: C. **
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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