Exogenous adrenaline is metabolished by
**Core Concept**
The metabolism of exogenous **adrenaline** (also known as **epinephrine**) involves several enzymes. **Catechol-O-methyltransferase (COMT)** and **monoamine oxidase (MAO)** are key enzymes in this process.
**Why the Correct Answer is Right**
Exogenous adrenaline is primarily metabolized by **COMT** and **MAO**. **COMT** initiates the metabolism by adding a methyl group, while **MAO** further breaks down the compound. This process occurs in various tissues, including the liver and kidneys.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not accurately represent the primary enzyme involved in adrenaline metabolism.
**Option B:** Similarly, this option is incorrect as it does not correctly identify the enzyme responsible for metabolizing adrenaline.
**Option D:** This option is also incorrect as it fails to recognize the role of **COMT** and **MAO** in adrenaline metabolism.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that **COMT** and **MAO** inhibitors can affect the metabolism of exogenous adrenaline, potentially leading to increased **adrenergic** activity.
**Correct Answer:** D. Monoamine oxidase and catechol-O-methyltransferase.