DIC is seen with all except –
**Core Concept**
Disseminated Intravascular Coagulation (DIC) is a complex, life-threatening condition characterized by both widespread clotting and bleeding in the vascular system. It is triggered by various underlying conditions, leading to a consumptive coagulopathy. DIC results from an imbalance between procoagulant and anticoagulant pathways.
**Why the Correct Answer is Right**
DIC is often seen in conditions that lead to endothelial damage, massive tissue injury, or severe inflammation. The activation of the coagulation cascade and the consumption of clotting factors and platelets result in a consumptive coagulopathy. Key factors that contribute to the development of DIC include the release of tissue factor, thrombin generation, and the activation of the fibrinolytic system.
**Why Each Wrong Option is Incorrect**
**Option A:**
DIC is commonly seen in sepsis, which triggers a massive inflammatory response and can lead to endothelial damage. Therefore, sepsis is a correct association with DIC.
**Option B:**
Malignancy, particularly pancreatic cancer, can lead to DIC due to the release of tissue factor and the activation of the coagulation cascade. This association is well-established in the literature.
**Option C:**
Pregnancy-induced hypertension, also known as preeclampsia, can lead to DIC in severe cases due to endothelial damage and the activation of the coagulation cascade.
**Clinical Pearl / High-Yield Fact**
A key clinical feature of DIC is the presence of microangiopathic hemolytic anemia, which is characterized by schistocytes on the peripheral smear and a low platelet count.
**Correct Answer:** D