All are examples of point mutation, except –
**Core Concept**
Point mutations are changes in a single nucleotide base in the DNA sequence, resulting in a change to the encoded amino acid sequence or the regulation of gene expression. These mutations can occur in coding or non-coding regions of the genome and have significant implications for protein function and gene regulation.
**Why the Correct Answer is Right**
Point mutations can be classified into different types based on the nature of the change, including:
- **Missense mutations**: A change in a single nucleotide base results in a codon that codes for a different amino acid, potentially altering the protein's function.
- **Nonsense mutations**: A change in a single nucleotide base results in a premature stop codon, leading to a truncated protein or a non-functional protein.
- **Silent mutations**: A change in a single nucleotide base does not result in a change to the encoded amino acid sequence, often due to degeneracy in the genetic code.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because [insert reason here].
* **Option B:** This option is incorrect because [insert reason here].
* **Option C:** This option is incorrect because [insert reason here].
* **Option D:** This option is incorrect because [insert reason here].
**Clinical Pearl / High-Yield Fact**
It's essential to remember that point mutations can have varying effects on protein function, ranging from complete loss of function to subtle changes in protein activity. Understanding the type of point mutation can provide valuable insights into the potential impact on protein function and disease development.
**Correct Answer:** A.