Example of IgA nephropathy is –
IgA nephropathy is a type of glomerulonephritis. The core concept here is probably the histopathological features or clinical presentation. Common features include hematuria, often after upper respiratory infections, and IgA deposits in the mesangium. So the question might be asking for an example of a clinical scenario or a diagnostic finding associated with IgA nephropathy.
Wait, the options are missing. The user probably intended to list options but forgot. Without the options, it's hard to know what the distractors are. But since the correct answer is given as, say, option C, I need to reconstruct the possible options. Maybe the options are different kidney diseases, and the correct one is IgA nephropathy. For example, options could be like "A. Membranous nephropathy, B. FSGS, C. IgA nephropathy, D. Lupus nephritis." But the question is phrased as "Example of IgA nephropathy is," which is a bit confusing. Maybe the actual question is "Which of the following is a feature of IgA nephropathy?" or "Which is an example of a mesangial proliferative glomerulonephritis?"
Assuming the correct answer is C, let's outline the core concept. IgA nephropathy is characterized by IgA deposits in the mesangium, leading to inflammation. The correct answer would highlight this feature. The wrong options would be other types of nephritis without IgA deposits. For example, membranous nephropathy involves IgG, FSGS has a different histology, and lupus nephritis has immune complex deposits but not specifically IgA.
The clinical pearl would be that post-infectious hematuria is a classic sign, and the diagnosis is confirmed by renal biopsy showing IgA deposits. The correct answer explanation would focus on the IgA deposits in the mesangium. Each wrong option is incorrect because they involve different immunological components or histological patterns.
So, putting it all together, the explanation should mention the core concept of IgA deposits in mesangium, why the correct answer is right (IgA in mesangium), why the others are wrong (different Ig or pathology), and the clinical pearl about hematuria after infections.
**Core Concept**
IgA nephropathy is a mesangial proliferative glomerulonephritis characterized by **IgA1 immune complex deposition** in the glomerular mesangium. It is the most common primary glomerular disease globally, often presenting with **hematuria** (especially post-infection) and **proteinuria**.
**Why the Correct Answer is Right**
The correct option (e.g., "Mesangial IgA deposits on renal biopsy") aligns with the **histopathological hallmark** of IgA nephropathy. The disease is diagnosed definitively by renal biopsy showing **IgA-dominant mesangial deposits** with complement C3. Pathogenesis involves aberrant glycosylation of Ig