**Core Concept:**

The core concept being tested in this question is the physiological response to significant blood loss, specifically the effects on blood pressure (BP) and heart rate (HR). Blood loss leads to a decrease in circulating blood volume, which in turn activates various reflexes and hormonal responses to maintain blood pressure and prevent tissue hypoxia.

**Why the Correct Answer is Right:**

In the context of significant blood loss (20% of the patient's blood volume), the correct answer is Option C:

**Why Option C is Right:**

A 20% reduction in blood volume will lead to a decrease in cardiac output due to reduced stroke volume. Cardiac output is the product of heart rate and stroke volume. When blood volume decreases, the heart has to pump against a higher pressure to deliver the same amount of blood, which results in an increase in heart rate (HR) to compensate for the reduced stroke volume. This is a reflex response known as the Bezold-Jarisch reflex, which aims to increase cardiac output and maintain tissue perfusion.

**Why Options A, B, and D are Incorrect:**

Option A (BP will increase) is incorrect because a 20% reduction in blood volume would lead to a decrease in cardiac output due to reduced stroke volume. In response, the body will increase heart rate (HR) to compensate for the reduced stroke volume. This increase in heart rate will not result in an increase in BP but rather a compensatory response to maintain cardiac output.

Option B (HR will decrease) is incorrect because the body's response to blood loss is to increase cardiac output. In order to increase cardiac output, the body will increase heart rate (HR), which is why Option B is incorrect.

Option D (BP will increase and HR will decrease) is incorrect for the same reasons as Option A and B. The body's response to blood loss is a decrease in stroke volume due to reduced blood volume, which results in a compensatory increase in heart rate (HR) to maintain cardiac output.

**Clinical Pearls:**

1. The Bezold-Jarisch reflex is an important physiological response in maintaining tissue perfusion during blood loss.
2. The body's primary response is to increase heart rate (HR) to compensate for the reduced stroke volume, not blood pressure (BP).
3. While blood pressure may transiently increase due to the reflex response, it is not the primary goal of the response to blood loss. The primary goal is to maintain cardiac output, which is achieved through increased heart rate (HR).

**Why Option C is Correct:**

In response to a 20% reduction in blood volume, the body will increase heart rate (HR) to compensate for the reduced stroke volume and maintain cardiac output. This increase in heart rate will not result in a corresponding increase in blood pressure (BP), but rather, it is the body's attempt to maintain tissue perfusion during blood loss.

**Why Options A, B, and D are Incorrect:**

Options A, B, and D are incorrect because they address the wrong physiological response. The body's primary response to blood loss is to increase heart rate (HR) to compensate for the reduced stroke volume, which is important for