CSF examination of a patient shows high protein markedly low sugar, low chloride and increased neutrophils. The diagnosis is –
**Core Concept**
The cerebrospinal fluid (CSF) profile described is indicative of bacterial meningitis, characterized by an elevated protein level, low glucose concentration, low chloride levels, and an increased white blood cell count with a predominance of neutrophils.
**Why the Correct Answer is Right**
The presence of high protein in CSF is due to the breakdown of the blood-brain barrier, allowing large molecules to pass through and accumulate in the CSF. The low glucose levels are a result of bacterial metabolism, which consumes glucose, leaving less available for the CSF. Low chloride levels are often seen in bacterial meningitis, possibly due to the inflammatory response. The increased neutrophils in the CSF are indicative of an acute bacterial infection.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not provided.
* **Option B:** This option is not provided.
* **Option C:** This option is not provided.
* **Option D:** This option is not provided.
**Clinical Pearl / High-Yield Fact**
In bacterial meningitis, the CSF to blood glucose ratio is typically less than 0.3, and the CSF protein to blood protein ratio is typically greater than 1:1. This can help differentiate bacterial meningitis from other types of meningitis, such as viral or tuberculous meningitis.
**Correct Answer:** C. Bacterial meningitis.