Esmolol is a short acting beta blocker because:
Correct Answer: Its plasma hydrolysis by esterases is rapid
Description: (Ref Goodman & Gillman's 13th ed. P 216-17)Esmolol is a b1-selective antagonist with a rapid onset and a very short duration of action (t 1/2 = 8 minutes).The drug is hydrolyzed rapidly by esterase's in erythrocytes leading to its short half-life.Esmolol is used in urgent settings where immediate onset of b-blockade is warranted so it is given by slow intravenous injection.A partial loading dose (500mg/kg over 1 minute) typically is administered, followed by a continuous infusion of the drug (maintenance dose of 50mg/kg/minfor 4 minutes)The lipid solubility of esmolol is low and has no oral bioavailability so it is given via IV.The protein binding of esmolol is 55%.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now