**Core Concept**
EBV (Epstein-Barr Virus) is a member of the herpesvirus family, known to cause infectious mononucleosis (also known as glandular fever) and various types of cancers, including lymphomas and carcinomas. EBV's association with certain malignancies is attributed to its ability to immortalize infected cells and evade the host's immune response.
**Why the Correct Answer is Right**
The correct answer, **C. Pancreatic carcinoma**, is incorrect because EBV has not been established as a causative agent for pancreatic cancer. In contrast, EBV is strongly linked to the development of **A. Glandular fever**, also known as infectious mononucleosis, which is characterized by symptoms such as fever, sore throat, and lymphadenopathy. EBV is also associated with **B. Burkitt's lymphoma**, a type of non-Hodgkin lymphoma that is prevalent in equatorial Africa, and **D. Nasopharyngeal carcinoma**, a rare cancer of the nasopharynx that is common in Southeast Asia.
**Why Each Wrong Option is Incorrect**
**Option A:** Glandular fever is indeed caused by EBV, making this option incorrect.
**Option B:** Burkitt's lymphoma has a well-established association with EBV, specifically the EBV-encoded nuclear antigen 1 (EBNA-1).
**Option D:** Nasopharyngeal carcinoma is also linked to EBV, particularly in populations with high incidence rates.
**Clinical Pearl / High-Yield Fact**
Mnemonic: "B-N-C" - Burkitt's lymphoma, Nasopharyngeal carcinoma, and Cervical carcinoma are all associated with EBV, while other types of cancers, such as pancreatic carcinoma, are not.
**Correct Answer:**
β Correct Answer: C. Pancreatic carcinoma
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