All the following diseases are associated with peripheral blood eosinophilia except :
**Core Concept**
Peripheral blood eosinophilia refers to an elevated count of eosinophils in the peripheral blood, which is a type of white blood cell involved in the body's immune response, particularly in fighting parasites and in allergic reactions. Eosinophilia can be caused by various conditions, including parasitic infections, allergic diseases, and certain types of cancer.
**Why the Correct Answer is Right**
Peripheral blood eosinophilia is a common feature in several diseases. For example, in **Hodgkin lymphoma (C)**, eosinophilia is a characteristic finding, particularly in the lymphocyte-predominant subtype. In **Chronic myeloid leukemia (D)**, eosinophilia can occur due to the overproduction of granulocytes. **Asthma (B)** is another condition associated with eosinophilia, as it involves an allergic inflammatory response that can lead to an increase in eosinophil count.
**Why Each Wrong Option is Incorrect**
* **Option A:** There is no information provided about this option, so we can't evaluate its correctness.
* **Option B:** While asthma is associated with eosinophilia, it is not the only option listed, so we can't conclude that this option is incorrect based on this information alone. However, we can consider other options to determine if they are correct or incorrect.
* **Option C:** This option is correct, as Hodgkin lymphoma is associated with peripheral blood eosinophilia.
**Clinical Pearl / High-Yield Fact**
When evaluating a patient with peripheral blood eosinophilia, it's essential to consider the patient's clinical presentation, medical history, and laboratory findings to determine the underlying cause of eosinophilia. A thorough investigation may involve imaging studies, endoscopy, and bone marrow biopsy to rule out malignancies and other conditions.
**Correct Answer:** D