Enzyme raised in myopathies is
**Core Concept**
The question is testing the understanding of specific enzyme markers associated with muscle diseases. Creatine kinase (CK) is a crucial enzyme found in muscle tissue, and its elevated levels are indicative of muscle damage or myopathies.
**Why the Correct Answer is Right**
Creatine kinase plays a vital role in the regeneration of ATP in muscle cells. When muscle tissue is damaged, CK is released into the bloodstream, leading to increased levels. This enzyme is particularly useful in diagnosing conditions like muscular dystrophy, rhabdomyolysis, and other muscle injuries. The elevation of CK is a direct result of muscle cell membrane disruption, allowing the enzyme to leak into the bloodstream.
**Why Each Wrong Option is Incorrect**
**Option A:** LDH (Lactate Dehydrogenase) - While LDH is also elevated in muscle damage, it is a non-specific marker and not as sensitive as CK for diagnosing myopathies. LDH is found in various tissues, including the liver, heart, and kidneys, making it less specific for muscle damage.
**Option B:** AST (Aspartate Aminotransferase) - AST is primarily found in the liver and heart, and its elevation is more indicative of liver or cardiac damage rather than muscle damage. Although AST can be elevated in muscle diseases, it is not a specific marker for myopathies.
**Option C:** ALT (Alanine Aminotransferase) - ALT is predominantly found in the liver and is a sensitive marker for liver damage. Its elevation is not typically associated with muscle diseases, making it an incorrect choice for diagnosing myopathies.
**Clinical Pearl / High-Yield Fact**
Remember the CK-MB isoenzyme, which is a more specific marker for cardiac damage, whereas the total CK level is elevated in both cardiac and skeletal muscle damage.
**Correct Answer: C. Creatine kinase (CK)**