**Core Concept**
The question tests the understanding of genetic diseases caused by enzyme deficiencies. These diseases occur due to mutations in genes encoding for enzymes, leading to impaired cellular metabolism and function. Examples of such diseases include glycogen storage disorders, lysosomal storage disorders, and fatty acid oxidation disorders.

**Why the Correct Answer is Right**
The correct answer is related to a specific enzyme deficiency. For instance, Pompe disease is caused by a deficiency of acid alpha-glucosidase (GAA), an enzyme involved in glycogen breakdown. Similarly, Gaucher disease is caused by a deficiency of glucocerebrosidase, an enzyme involved in lipid metabolism.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as it does not specify a particular enzyme or disease.
**Option B:** This option is incorrect as it is not a specific enzyme deficiency.
**Option C:** This option is incorrect as it is not a known enzyme deficiency causing a genetic disease.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that enzyme deficiencies can be caused by mutations in genes encoding for enzymes, leading to impaired cellular metabolism and function. This can result in a wide range of genetic diseases, including glycogen storage disorders, lysosomal storage disorders, and fatty acid oxidation disorders.

**Correct Answer:** D.