Enzyme associated with hyperuricemia:
Correct Answer: All of the above
Description: Uric acid is the end product of purine metabolismHyperuricemia refers to an elevation in the serum uric acid concentration.In type I glycogen storage disease (von Gierke's), glucose 6-phosphate can Not be conveed to glucose due to the deficiency of glucose-6-phosphatase.This leads to increased utilization of glucose-6-phosphate by hexose monophospahet shunt (HMP shunt), resulting in increased levels of ribose-5-phosphate and PRPP, and ultimately purine overproduction.Von-Gierkes disease is also associated with increased activity of glycolysis. Due to this, lactic acid accumulates in the body which interferes with the uric acid excretion through renal tubulesThe lack of feedback control by PRPP glutamylamidotransferase by purine nucleotides also leads to their elevated synthesisXanthine oxidase is an impoant enzyme that conves hypoxanthine to xanthine, and xanthine to uric acid.
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now