**Core Concept**
The patient's presentation suggests a liver lesion, likely a hepatocellular carcinoma (HCC), given the presence of hepatomegaly without jaundice, and a solitary hypoechoic lesion on ultrasound. HCC is a common primary liver malignancy, often associated with chronic liver disease or cirrhosis.

**Why the Correct Answer is Right**
The initial treatment for HCC depends on the tumor size, number, and the patient's liver function. For a solitary lesion like this, the preferred treatment is surgical resection or ablation (e.g., radiofrequency ablation, RFA). However, since the patient's liver function is not mentioned, the best initial approach would be to assess the liver function and consider a liver transplant if the patient has underlying cirrhosis or poor liver function. The correct answer is surgical resection or ablation.

**Why Each Wrong Option is Incorrect**
**Option A:**
This option is incorrect because surgical resection or ablation is not the initial treatment. The patient needs to undergo further evaluation, including liver function tests and imaging, before deciding on a treatment plan.

**Option B:**
This option is incorrect because liver transplant is not the initial treatment. While liver transplant is a treatment option for HCC, it is typically considered after surgical resection or ablation has been ruled out or in patients with underlying cirrhosis or poor liver function.

**Option C:**
This option is incorrect because chemotherapy is not the primary treatment for HCC. Chemotherapy may be used in advanced cases or as a bridge to transplant, but it is not the initial treatment of choice.

**Option D:**
This option is incorrect because embolization is a treatment option for HCC, but it is typically used in patients who are not candidates for surgical resection or ablation.

**Clinical Pearl / High-Yield Fact**
For patients with HCC, the Barcelona Clinic Liver Cancer (BCLC) staging system is a useful tool to guide treatment decisions. The BCLC system takes into account the tumor size, number, and the patient's liver function to determine the best treatment approach.

**Correct Answer:** C.