Medical MCQ - ELISA is performed on a population with low prevalence. What would be the result of performing double screening ELISA tests -

ELISA is performed on a population with low prevalence. What would be the result of performing double screening ELISA tests –

Increased sensitivity and positive predictiv value

Increased sensitivity and negative predictive value

Increased specificity and positive predictive value

Increased specificity and negative predictive value

Question Category:

Social & Preventive Medicine

Correct Answer:

Increased specificity and positive predictive value

Description:

The specificity of ELISA can be increased by carrying out ELISA in a row (series) using different HIV markers. When screening test is used in a series mode : -↑ Specificity ↑ PPV ↓ Sensitivity

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