Arrange the Electrophoretic pattern of serum lipoproteins in sequence staing from point of origin: A. Alpha lipoprotein B. Pre-beta lipoprotein C. Chylomicron D. Beta lipoprotein
**Core Concept**
The question tests the understanding of serum lipoproteins and their electrophoretic patterns. Serum lipoproteins are classified into different types based on their density and composition, including **chylomicrons**, **beta-lipoproteins** (LDL), **pre-beta lipoproteins** (VLDL), and **alpha-lipoproteins** (HDL).
**Why the Correct Answer is Right**
The correct sequence from the point of origin (cathode) towards the anode in electrophoresis is based on the charge and size of the lipoproteins. **Alpha-lipoproteins** (HDL) have the highest charge and migrate farthest towards the anode, followed by **pre-beta lipoproteins** (VLDL), then **beta-lipoproteins** (LDL), and **chylomicrons** remain closest to the origin due to their large size and low charge.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because alpha-lipoproteins migrate the farthest, not the least.
**Option B:** Incorrect as pre-beta lipoproteins migrate after alpha but before beta-lipoproteins.
**Option C:** Incorrect because chylomicrons, being the largest and least charged, stay closest to the origin.
**Clinical Pearl / High-Yield Fact**
Remembering the sequence can be aided by recalling that **HDL** (alpha) is the "good" cholesterol, which migrates the farthest, and **LDL** (beta) is the "bad" cholesterol.
**Correct Answer:** D. Alpha lipoprotein, Pre-beta lipoprotein, Beta lipoprotein, Chylomicron